To make this determination, we mapped each FAIME-derived overlap (the commonly shared mechanisms among all three datasets) back to their constituent genes and then examined their overlap.
We found a significant overlap of commonly observed under- and overexpressed genes in the cytokine-cytokine receptor interaction pathway comparing PA I and GBM IV (overlap: 20 genes, 1 underexpressed, 19 overexpressed genes, P<2.5×10−42, Fisher's exact test).
The large overlap of commonly enriched TFBS between all test systems and compounds provides evidence for the existence of a set of 'common transcription factors' (including, e.g., E2F, ETF, SP1 and AP-2 (Fig. S8).
The cytokine receptor pathway showed nearly the same number of differentially expressed genes in PA I and GBM IV and was further characterized by a significant overlap of commonly altered genes and an exclusive enrichment of overexpressed cancer genes in GBM IV.
Irrespective of the specific nature of these health problems, these general results are in line with findings from other studies confirming the common occurrence of diverse, overlapping and commonly chronic physical and mental health problems among marginalized drug user populations, and specifically crack user populations [ 9, 23, 24, 26, 59, 60].
These efforts are especially prevalent in East African rangelands where pastoralists, livestock, and wildlife commonly overlap outside of formal protected areas.
The method does not assume any prior knowledge about the point ordering and performs well in the presence of the measurement noise, while also bypassing the problems of occlusion and overlap that are commonly associated with range imaging.
Additionally due to their fabrication design, the microelectrodes comprising the array are sufficiently separated to ensure no diffusional overlap which is commonly encountered by microelectrode arrays reported within the literature.
Otherwise, as discussed below, the overlap of genes commonly up-regulated in the different data sets was comparatively small (Table S18).
These gene pairs commonly overlap in animal mt genomes.
