In the overlaid structures, the base and ribose groups of AMPPNP bulge out from the binding pocket, implying that ZIKV helicase would lack nucleotide specificity for its NTPase activity.
The overlaid structures are shown at the bottom left.
These indicated inward (blue) or outward (red) remodelling between overlaid structures, with negative or positive values, respectively.
The two overlaid structures clearly show that the N346 side chain is adjacent to the ortho position of the O-methyl-tyrosine side-chain phenyl group.
The aligned string of (in variant sites for sauropsid Gal-1As, sauropsid Gal-1Bs, mammalian Gal-1s, and amphibian Gal-1s was reconciled with the overlaid secondary structure (locations of β-strands [S1 S6b, F1 F5]).
On the other hand, the least potent analog 4 adapted a different pose in the ion permeation path altogether (see Supplementary Figure 2, Supporting Information, for overlaid crystal structure of ouabain and docked ouabain and analogs).
Based on this result, we further overlaid ZIC3 ZF1–3 structures with Kpna1 that has been co-crystallized with nucleoplasmin NLS (Fig. 10B).
For the description of the riboswitch structures, I prefer to see the apo and the bound structure overlaid to form a better opinion on the extent of structural rearrangement of the two.
With ESRI's technology, GoodLands will be able to visualize and analyze the data to present a global landscape of holdings overlaid with the structure and population distribution of the one billion-plus Catholics globally.
Following majority rule in early 1980, British Army trainers oversaw the integration of guerrilla fighters into a battalion structure overlaid on the existing Rhodesian armed forces.
