"The longer they put it off, the more of an overhang it will be on the stock, both psychologically and financially," Mr. Greenfield said.
Thus, the RNA duplexes having the thymidine dimers with the carbamate or urea linkage at their 3′ overhang regions will be promising candidates for novel siRNA molecules to down-regulate protein expression.
Thus, the rate constant of reaction 1 is 0.008 for siRNAs with 2-nt overhangs while it will be approximately 0.004 for the blunt-ended molecules.
Don't worry about overhang material, as it will be trimmed and tucked later.
There will be an overhang.
Still, that geopolitical situation will be an overhang".
And of course, as the budget made clear, the only way to clear a huge debt overhang in the medium term will be to cut billions of pounds from public spending.
If these two can be dismissed as the usual suspects, then what about Ruth Kelly, who argued in the Guardian last week that "the budget made clear that the only way to clear a huge debt overhang in the medium term will be to cut billions of pounds from public spending"?
Along with its downgrade Friday, Moodys says it believes that uncertainty over the ultimate cost for massive litigation claims and other contingent liabilities will be an overhang on BP's creditworthiness that will persist for years to come..
"From an industry standpoint, the take-away is that there is definitely excess inventory, but they'll utilize extensive outlet store business, and they'll try to keep the channel as clear as possible," says Robert Drbul Robert Drbul, research analyst at Lehman Brothers, noting that there will be an overhang on the stock until there is clear visibility.
