Additionally, compared to their paralogs, less functional data about overhangs is available.
S&P sees "little upside potential over next 12 months," based on its view of competitive pressures, signs of moderating high-speed data growth and overhang from a potential bid for Adelphia Communications.
Similar results were seen for strand exchange reactions using PstI-cut linear ds pGEM substrates (generating a 3' overhang) and ΦX174 DNA substrates (data not shown).
Direct interaction data confirm that overhangs do not seem to be associated with their paralog's protein complex.
However, we included all indications into our analysis, and subsequent evaluations of the data found that the overhang significantly differs between indications (p = 0.031).
Here's how I interpret what we see in the historical data: financial crises leave an overhang of private-sector problems, principally excessive debt on the part of some subset of economic agents — households, in the case of the United States.
The measure of binding overhang is expressed using weighted average tariff data.
Validation with TAP protein complex purification data shows virtually no association of overhangs with their paralog's module (average interaction spoke value for overhangs is 0.06 compared to 2.6 for their "in-module" partners).
The putative path for RNA agrees well with biochemical data indicating that a 3′ single strand overhang of 7 10 nt is necessary for binding and hydrolysis by RNase II.
Collectively, these data demonstrate that WRN exonuclease activity on 3' overhangs of telomeric DNA substrates is strictly dependent on the presence of perfect telomeric TTAGGG motifs in both double-stranded and single-stranded regions of the substrate.
