Second, by using overestimation of the constraints, the deleting operation consists in eliminating each subbox D generated by the division operation, in which there is no feasible solution.
Hence, to effectively tighten the variable bounds in a particular node, a valid range reduction strategy is introduced by overestimation of the constraints, and by applying the monotonic decompositions to problem (P).
However, taking into consideration the probable overestimation of the temperature and other constraints indicating a temperature ≥400°C, we concluded that the peak temperature was 400°C to 626°C, corresponding to an apparent friction coefficient of 0.01 to 0.06.
It is likely that this relaxed constraint leads to the overestimation of the number of such copies.
However, the use of strong constraints (gene transfer ≤3) signifies a possible overestimation of the number of codivergence events and a probable underestimation of gene transfers.
Over constraint of the artery ends can lead to an overestimation of recoiling effect of the system.
In this regard, possible functional constraints on the nucleotide compositions will tend to contribute to an overestimation of recent horizontal gene transfers in viruses relative to prokaryotes.
In our opinion, the high end of the range is implausible because of (1) overestimation of the area available for bio-energy crops due to insufficient consideration of constraints (e.g., area for food, feed or nature conservation) and (2) too high yield expectations resulting from extrapolation of plot-based studies to large, less productive areas.
Finally, the reviewers also ask whether a constraint on the minimum number of subunits might lead to an overestimation of subunit size.
The problems which can arise from the overall analysis of a MLS data set in which loci do not share congruent evolutionary constraints include, among others, misleading inferences of genetic relatedness and phylogenetic relationships [ 7] or overestimation of linkage disequilibrium [ 8].
