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As shown in Figure 1, we may notice that all the individual model predictions show great variability, in which the toxicity is overestimated by using ECFP4 and FCFP4, but is underestimated by using MACCSS and DES.
The results indicate that these predictions on one-way specimens agree well with the testing data, while the performance of two-way specimens is overestimated by using these three methods.
Moreover, the proportion of functional sites among all predicted sites is expected to increase with higher, more stringent PWM scores, so that the background frequency of site predictions could be overestimated by using sequences of regulated genes.
Additionally, the prevalence of CKD might have been overestimated by using the Bayer's multistix 10 which detects urine protein, not albuminuria.
The curve patterns resemble the ones displayed in Figure 4. Results from the data analyses suggest that the true mean score might be overestimated by using the observed mean score, which equals the arithmetic average of the observed score values at a given control week.
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It is difficult to identify bilingual patients thus test-retest agreement may have been overestimated by use of the instrument in a generally healthy population (university students).
If children with LI who read accurately do so slowly and laboriously, then their literacy attainments could have been overestimated by use of an untimed reading test (see Fuchs, Fuchs, Hosp, & Jenkins, 2001).
The prevalence of obesity was underestimated by 5%35%5% using measured and 30% using self-report) and prevalence of normal weight was overestimated by 5%27%7% using measured and 32% using self-report).
CMS is potentially nephrotoxic but the incidence of kidney injury is probably overestimated by currently used criteria (e.g., the RIFLE classification) and may be influenced by manufacturer-dependent differences in dose recommendations.
Compared to Bremer support, theoretical considerations show that there is a lower risk of significantly overestimating support by using less thorough searches (enhanced type I error of accepting a clade that in fact is not there).
When including and accounting for prevalent psychiatric cases, all-cause mortality risk among persons with any mental disorder was overestimated by 15.3% using only inpatient diagnoses (adjusted hazard ratio [aHR], 5.89; 95% CI, 5.85 5.92) vs. both inpatient and outpatient diagnoses (aHR, 5.11; 95% CI, 5.08 5.14).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com