This would imply that radically new design approaches are needed to propel the clinical integration of nanomedicines, overcoming well-accepted clichés.
In anticipation of the requirement for value sets to accompany the new EQ-5D-5L, thEuroQol Groupup initiated a programme of methodological research, aimed at overcoming well-known problems and limitations with the time trade-off (TTO) approach that had been used in valuing the three-level version of the EQ-5D and testing the use of discrete choice (DC) methods to value EQ-5D-5L.
Labour often requires a large swing to overcome well entrenched and well organised Lib Dem incumbents, so even a relatively modest leakage to the Greens could make life difficult.
Evidence has shown that combined MAP treatment and low temperature storage can overcome well the problem [16, 17].
However, we advise caution that spaceborne imaging spectrometer data of improved quality will not completely help to overcome well known phenomena of spectral similarity between materials and spectral confusion caused by the presence of shaded areas.
The centre-right Social Democrats overcame well-known incumbents in Socialist strongholds like Lisbon and Oporto, to the surprise even of those who defeated them.Mr Guterres accepted the defeat as a vote of no confidence, and offered his resignation.
The variable-gain strategy is used to overcome well-known linear control design trade-offs between low-frequency tracking properties and high-frequency noise sensitivity.
To overcome well-known problems with polar singularities, we consider the shallow water equations in Cartesian coordinates, augmented with a Lagrange multiplier to ensure that fluid particles are constrained to the spherical surface.
To overcome well-known difficulties of estimating ecologically meaningful toxicity parameters, we used novel Dynamic Energy Budget and Toxicodynamic (DEBtox) modeling techniques to evaluate impacts of ENPs on population growth rates.
