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However it is clear that the action of ABC transporters in the BBB decreases the accumulation of hydrophobic TPP cations into the brain and that overcoming this action of the BBB would significantly improve the targeting of therapeutic molecules and probe molecules to mitochondria in the brain in vivo.
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In the present study, the capability of this bridge type to easily overcome this accidental action, with a higher degree of safety than that required by codes, is clearly demonstrated.
This is because the hormone must first overcome the action of miR-965 before it can kick off the positive feedback loop.
To overcome this problem, we perform action set reduction and state aggregation to reduce the complexity without loss of optimality.
Bacteria and other microorganisms can adopt diverse mechanisms to overcome the action of organic solvents.
Inhibition of cell-cycle of cells lacking asparagine synthetase could favour the proliferation of those carrying the enzyme, thus becoming more suitable to overcome the action of an L-asparagine deficiency.
In summary, activated Notch can overcome the action of Esg to induce differentiation.
For instance, P. infestans has evolved an arsenal of protease inhibitors to overcome the action of plant proteases [ 42].
Nuclear Rfs seem to overcome the action of S factors in different ways, but the mechanisms are obscure.
But in other segregating populations the situation was more complex, suggesting that genetic modifiers can overcome the action of the Wx allele [ 25].
However, it should be noted that some papers have shown that cell-to-cell spread cannot overcome the action of most anti-HIV-1 drugs (Titanji et al., 2013; Agosto et al., 2014).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com