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To directly determine if endogenous Smac was responsible for overcoming the function of XIAP in this tBid-mediated death, we isolated myoblasts from Smac-deficient mice.
In SD genotypes of wild strawberry, SD or low temperature induce flowering [ 27] probably by overcoming the function of SFL repressor gene.
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Our experiments suggest that in order for myotubes to undergo apoptosis, they would not only have to release cytochrome c but also overcome the function of XIAP in order to become competent to die.
An explanation may be that this time period is sufficient enough to overcome the function of RGD peptides on promoting initial cell adhesion and proliferation.
ROS overproduction above the physiological level can overcome the functions of cellular antioxidant system leading to oxidative stress.
In conclusion, the microneedle arrays used in this study are able to overcome the barrier function of the skin in human volunteers, are painless and cause only minimal irritation.
In order to investigate the mechanism by which NAC overcomes the suppressive function of Tregs, it was necessary to identify the suppressive mediator or factor in the assay.
2) The authors nicely complement their previous studies showing that IL-6 overcomes the suppressive function of Treg cells.
(22, 23) It overcomes the inhibitory function of 53BP1 on DSB end resection and promotes HR (20) (Fig. 1d,e, middle).
Overcoming the reduction in function of a hypomorphic mutation is achieved through an increase in expression levels, that is, compensation.
Although BCL-xL protein levels also increased, the ratio of BIM BCL-xL expression rose suBIM BCL-xLy ovexpressionuggesting heightened Bim exproseion represubstantiallying pover" for overcoming timeanti-apoptotic function of BCL-xL and related proteinsuggestingng mitocheightenedepolarization.
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