There is a challenge in overcoming dose-limiting myelosuppressive toxicity of TMZ while maintaining its efficacy.
Currently, there is a challenge in overcoming dose-limiting myelosuppressive toxicity of TMZ while maintaining its efficacy.
How to overcome dose-limiting myelosuppressive toxicity of TMZ while maintaining its efficacy?
Therefore, these results supported ACA's potential to overcome dose-limiting toxicities brought upon by CDDP, while maintaining a similar, if not, higher efficacy level.
Overcoming the dose- and time-dependent action, Layered Double Hydroxides- (LDHs-) based systems of drug delivery have recently been demonstrated to deliver better molecules in vitro and in vivo bioactive to cells [ 59].
In cases without prior irradiation, the combination with EBRT also allows safe dose escalation to overcome the dose limitations of EBRT alone as shown in advanced primary rectal cancer [ 18].
Only over-expression of the Pap1, but not Sty1, pathway has arisen as beneficial in overcoming high doses of caffeine [9], [10].
In our study, we observed comparable results (local control 83%) using intraoperative radiation therapy (IORT) as a boosting strategy in combination with maximal surgery and moderate doses of external beam radiotherapy to overcome the dose limitations mentioned above.
Missing tissue compensators (TCs) can overcome this dose inhomogeneity.
Poor lung penetration of drugs can be overcome by dose increases, but this management approach is often limited by the associated risk of systemic adverse events; for example, high systemic concentrations of aminoglycosides are associated with nephrotoxicity and ototoxicity [19, 20].
It has been authoritatively documented that partial Gleevec resistance can be actively overcome by dose escalation of Gleevec from 600-1600mg/day (32).
