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This retrovirally-based expression library was used in two independent unbiased genetic selection assays aimed at overcoming cell death induced by the chemotherapeutic 5-FU or the cytokine TNF-α.
In this study we used the library in two functional genetic selection assays to identify small RNA effectors capable of overcoming cell death induced by a chemotherapeutic agent (5FU) or a cytokine (TNF-α).
Recently, a set of statistical methods have been published aimed at overcoming cell composition bias in EWAS.
These findings indicate that YAP may play a critical role in overcoming cell contact-induced inhibition of cell growth.
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However, a long follow-up is required before concluding that these strategies will overcome cell resistance.
Combining efforts to overcome cell turnover together with appropriate animal models will enable the field to make continued progress and to reach the step into the clinic.
To overcome cell death caused by reaction products from in situ polymerization, we encapsulated bone marrow-derived stem cells (BMSCs) in fastdegrading, oxidized alginate beads prior to mixing with the hydrophobic precursors.
The purpose of this study was to produce small and narrow-sized cationic nanoparticles able to overcome cell membranes and improve the biological activity of benznidazole (BNZ) in normal and cancer cells.
The shortcomings of current therapeutic modalities are highlighted and a broad spectrum strategy using approaches including (a) gossypol; (b) epigallocatechin-3-gallate; (c) UMI-77 (d) triptolide and (e) selinexor that can be used to overcome cell death resistance is presented.
The rationale for HDCT is that escalating doses of HDCT may increase survival by capturing putatively remnant malignant cells and thus overcome cell resistance to standard chemotherapy [7].
The up-regulation of genes encoding proteins of cell wall biosynthesis may help the organism to overcome cell surface-damaging components present in BALF.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com