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To overcome variance in pre-analytic processing including differences in cold ischemia time, formalin fixation, processor protocols, and storage that likely differed among sites, staining intensity was assigned with reference to an internal control.
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However, since the previous studies did not consider various uncertainties that exist in the energy harvester, it is difficult to overcome the variance of performance caused by the uncertainties.
This allows the segmentation algorithm to overcome minor variances in the data that could arise from noise in the data.
It can be overcome by allowing variance at the R locus through secondary "back" or null mutations from A to the a allele which lacks regulatory ability (Additional file 2).
For each set of assays a standard curve using pure ATP (Sigma, St . Louis MO) in serial dilutions was carried out to overcome any experimental variances, operator differences, and instrument discrepancies, etc.
PCA features are quantized to obtain a 128-bit feature vector from which 64 distinguishable bits are indexed in a look-up table while variance is overcome by Reed-Solomon codes.
Given the complex and often variable nature of diesel exhaust exposures, protein adducts provide a very attractive alternative for overcoming the high variance associated with more traditional measures such as parent or metabolite levels in a blood or urine specimen.
Furthermore, in order to make the comparison across all variables simultaneously and to track the ranking of the groups, we have considered the standardised average values from the variance matrix, to overcome the constraint linked to the different units of measurement without losing the variation between the values.
We illustrate this with regard to this example below but first detail several problems that must be overcome in order to get variance components for all explanatory variables.
In order to overcome an underestimation of the variance due to data from within a Danish twin pair being highly correlated, the twin pairs were treated as clusters in the estimation of the correlations and their variances.
To overcome the problem of skewed variance, the DNA methylation data were arcsine transformed.
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