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However, we also summarize the limitations and challenges that will have to be overcome to exploit fully miRNA technology.
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We also suggest design strategies and hurdles that still need to be overcome to fully exploit their therapeutic potential.
Measuring tracks is difficult in the LHC environment and many challenges had to be overcome to fully exploit the potentialities of the accelerator resulting in a detector of unprecedented complexity and size.
First results gained with a prototype printhead show that successful droplet generation is possible, but that pollution of the melt with oxides and sparks developing during the droplet generation process have to be overcome to fully exploit the potential of the proposed print head.
This emphasis on the dual use threat associated with discrete "pieces" of research fails to take into account the complexity of innovation processes and the intangible barriers that would need to be overcome in order to exploit any single "piece" of research for the purposes of bioweapons development (second unknown known).
This strategy allowed us to overcome matrix effects and to exploit second-order advantage.
So far, chemotherapy and radiotherapy specialists have faced this heterogeneity as obstacles to be overcome while we propose to exploit these properties and use environmental barriers to trap the tumor in its own microenvironment and reduce its resistance to treatment.
Mebs [ 45] argued that there is no evidence that strong selective forces drive the development of more potent toxins to overcome prey resistance, or to exploit new biochemical pathways for more effective intoxication of prey.
Following on from work pioneered by the late Ged Adams, many attempts have been made to overcome and exploit tumour hypoxia both because it is a unique feature of tumours, as opposed to normal tissues, and because hypoxia underlies the radio-resistance of many solid tumours.
This review summarizes our current understanding of how CD4+ T lymphocytes impose these individual barriers, describes mechanisms by which HIV-1 seeks to overcome or exploit these blocks, and discusses potential pathophysiological consequences of productive and non-productive HIV-1 replication in this large reservoir of target cells.
To overcome this problem, we propose to exploit the specific nature of the environment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com