Sentence examples for overcome this target from inspiring English sources

To overcome this "target ID" bottleneck, new technologies are being developed that analyze protein drug interactions, such as drug affinity responsive target stability (DARTS), which aims to discover the direct binding targets (and off targets) of small molecules on a proteome scale without requiring chemical modification of the compound.

Even though some classification models based on integrated drug features considering comprehensive chemical and pharmacological properties have overcome this "target-only" issue; however, the current number of effective drug combinations and their obtainable properties will limit the performance.

The propensity of mutations in a target sequence to form non-unique reads and therefore the probe length required to overcome this is target specific.

Therefore, to overcome this problem, targeted drug delivery systems such as thermo-, pH-, ultrasound-, and optical-sensitive liposomes have been studied [9, 10].

To overcome this limitation, targeted serum shift prediction models were generated for each subclass of interest and were applied to the design of prospective analogs.

Viral vector models were able to overcome this by targeting the basal ganglia directly through injection into the SN and have been shown repeatedly to produce a progressive nigrostriatal degeneration along with motor impairments.

New high-throughput methods are being developed to overcome this bottleneck, particularly targeted mass spectrometry (MS) methods such as selected reaction monitoring MS (SRM-MS).

One approach to overcome this challenge is to target the cellular hypoxia inducible factor (HIF-1α) pathway, which responds to low oxygen concentration (hypoxia) and results in the activation of numerous pro-angiogenic genes including vascular endothelial growth factor (VEGF).

One approach to overcome this problem is to target the delivery of cytokine to the specific diseased tissue.

To overcome this drawback, we propose a target localization algorithm based on local gradient ascent.

Fused glass beads can be an adequate target to overcome this problem (Park et al. 2013 and references therein).