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To overcome this defect, glucosyl thiamine disulfide prodrugs 1a 1c incorporating naproxen were designed and synthesized.
Hence, if MEKi is detrimental to T-cell function, combination with immune agonists may overcome this defect, which may lead to significantly improved therapeutic efficacy.
To overcome this defect, model checking as an automatic technique for the verification of the systems is a suitable solution.
To overcome this defect, we developed an improved bistable energy harvester (IBEH) from BEH by adding a small magnet at the middle of two fixed magnets.
To overcome this defect a direct method of estimating the advance in stand development due to Type 1 responses is suggested.
In order to overcome this defect, Schmidt and Witte (1989) put forward the split-population model.
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While our finally proposed measure ReTSP-Trend overcomes this defect, taking into consideration the trend of time series and the direction of forecasting error.
Overexpression of rv1219c in M. bovis BCG overcomes this defect.
Conjugation of polysaccharide to protein carriers overcomes this defect, improving memory responses and increasing immunogenicity in children under 2 years of age (Knuf et al, 2011).
To overcome this latter defect, "heat-seal" adhesives were introduced in the late 1960s.
This manifests as delayed neuronal commitment, but not as altered fate choice as the these cells are able to overcome this initial defect and recover normal numbers of neuron-like cells after a further week in culture.
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