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To overcome this confounding factor, we exposed cells to the f-actin polymerization inhibitor cytochalasin D, which itself had no effect on the concentration of cellular SNO, compared to uninfected cells without cytochalasin D treatment (data not shown).
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The Lothian Birth Cohort 1936 LBC19366) 6, 7 offers an opportunity to overcome this confound.
The selection of unique responses, using trial specific stimuli (Lau et al. 2004), single words (Desmond et al. 1998) or first-only responses in healthy controls (Rowe, Hughes, Nimmo-Smith et al. 2010), partly overcomes this confound but is inconsistent in the distinction between the roles for the prefrontal cortex and striatum.
However, in all contrast analyses we only included correct trials to overcome this potential confound.
However, in the present study, we can overcome this potential confound by showing that perirhinal activation was not correlated with correct or incorrect trials.
To overcome this possibility of confounding, we took in the regression analysis the number of DMARDs prescribed at each time point into account.
In order to overcome this potential source of confounding whereby patients with certain characteristics might be channeled to particular therapies, analytic adjustment will be performed to maximize the validity of treatment comparisons by reducing confounding, and improve precision.
Therefore, we used a binomial test (see Materials and Methods) to overcome the confounding phylogenetic effect.
The subjective top-scoring method was shown to overcome the confounding of ideational originality and fluency while concurrently providing highly reliable and valid scores (Benedek et al., in press; Silvia et al., 2008).
Additionally, while there were differences in baseline characteristics between groups which may have confounded the results a larger randomised trial would overcome this.
We attempted to overcome this weakness through multiple regression modeling, and our findings were resilient to multiple modeling strategies, but it is possible that unmeasured confounding remains.
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