Sentence examples for overcome the targeted from inspiring English sources

Finally, we evaluated the ability of the methodology to overcome the targeted limitations.

In this study, the authors show that it is possible to overcome the targeted delivery of SNALPs as well as miRNA encapsulation efficiency drawbacks by conjugating SNALPs with the transferrin and chemically modifying the miRNA with a 2′-O-methylation.

Building RNA-guided gene drives based on the Cas9 nuclease is a logical way to overcome the targeting and stability problems hindering gene drive development.

Indeed, cancer cells overcome easily the targeting of a single genetic aberration through development of resistance.

Another issue to be overcome is the targeting of collagen turnover specifically in the heart; because turnover rates in the heart seem to be somewhat higher than in other tissues such as the skin, it is possible that anti-fibrotic treatments would have a greater impact in the heart than elsewhere [ 81, 82], reducing off-target effects.

Such materials can overcome the off-target side effects, solubility, and stability issues of current therapeutics.

Alternatively, gene editing of somatic cells followed by reprogramming to iPS cells and subsequent expansion and redifferentiation into HSCs can be exploited to overcome the low gene targeting efficiency.

Peptides have been used for radionuclide targeting of tumors to overcome the difficulties in tumor targeting with mAbs mentioned above.

Recently, several databases of experimentally validated miRNA targets are established to overcome the unreliability of target prediction.

In this work, we have designed and fabricated a nanoparticle (NP) construct that could potentially overcome the current limitations of targeted in vivo delivery.

We have not overcome the core economic challenges targeted by the Civil Rights movement.