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Conversely, covalent linking of individual protein subunits into single polypeptide chains are exploited to overcome sample preparation bottlenecks.
Additionally, a new multivariate approach to overcome sample matrix effects is proposed to handle variation in the blister packing material between different production batches.
To overcome sample carryover contamination and surface adsorption associated with microfluidic PCR, microdroplet technology has recently been utilized to perform PCR in droplets, which can eliminate the synthesis of short chimeric products, shorten thermal-cycling time, and offers great potential for single DNA molecule and single-cell amplification.
We also used a semi-supervised algorithm that leverages unlabeled data to overcome sample heterogeneity and improve performance.
Four 0.6-mm cores were collected from different areas of each tumor block in order to overcome sample heterogeneity and the possible loss of tissue due to cutting.
By utilising the wealth of samples already collected and preserved in FFPE, we overcome sample limitation and facilitate the design and execution of better and more abundant studies in many more centres.
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Enhanced biopsy strategies have been proposed as one means to overcome sampling variation and errors.
In addition, a household mapping and listing exercise was done prior to household randomization to overcome sampling bias.
As current practice dictates random four-quadrant biopsy, it is difficult to overcome sampling error, although promising new cytological techniques, that sample a larger field of the Barrett's segment are being investigated (Lao-Sirieix et al, 2009).
As CTCs and circulating cell-free plasma DNA (cfDNA) are likely to originate from tumor cells and thus correlate with disease burden and may overcome sampling bias, blood biomarkers may serve as a surrogate for spatial heterogeneity and as a marker for temporal heterogeneity.
Because selection is expected to overcome sampling error (genetic drift) whenever the selection coefficient exceeds the reciprocal of Ne of the X chromosome, even very low levels of sib-competition and sib-mating would be sufficient to favor SK in D. simulans.
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