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Notably, the recombinant BCG strain Aeras 422, that showed promising results in animal models, failed to overcome phase 1 trial, do to some reactivation of shingles in vaccinated healthy adults [ 79] and the development of rBCG30 strain, an overexpressing Ag85B recombinant vaccine that showed safety and immunogenicity in a phase 1 trial, did not carry on [ 80].
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Nonetheless, both groups highly depend on durable structures to overcome phases of transportation and rest in ephemeral nectar habitats.
The animal studies suggest that the negative effects of phase I CYP activity may be overcome by phase II enzyme activity, thus demonstrating the interdependence between phase I and phase II detoxification enzymes.
One of the most frequent usages of POMs in crystallography is their use in the phasing of macromolecular crystals to overcome the phase problem.
In order to assess phase changes over time, we developed methods to overcome temporal phase wrap as well (see appendix §A.5 for details).
"We thought we had clearly overcome this phase in Spain.
This limitation might be overcome by phase variation, as observed for other mucosal pathogens.
In addition to this some important issues will need to be overcome before phase III efficacy trials of new tuberculosis vaccines in young children can be carried out.
Altogether, our data strongly support that stathmin overexpression is required in HG-EOC cells to overcome M phase failure and drug-induced cell death, particularly following exposure to alkylating agents.
The capacity of CRs to stack, weakening protein protein repulsive forces, appears to make them ideal additives that can help overcome the phase transition barrier between the solvated and crystalline protein states.
This ancestral population overcame the phase of deposition of evaporites of the so-called "Messinian Salinity Crisis", which was dated precisely at 5.96-5.59 Ma [ 28] and was coeval with a generalized marine regression episode that could have dried up the Mediterranean completely at that epoch.
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