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The new algorithms overcome one of the major impediments to the application of profile HMMs in the transposon modeling problem: that of poor parameter estimation.
The major impediment overcome in the clinical implementation of this microcomputer-based system was the rapid Fourier transformation of pulsatile pressure and flow waveforms from time domain to frequency domain.
This was cited as one of the major impediments by the majority of the respondents.
Structural problems, however, are major impediments to economic growth.
The global recession and unfavorable exchange rates have been the major impediments.
A large trade deficit and a high rate of unemployment are major impediments to economic progress.
Collectively, these and other factors lead to major impediments in learning and development.
Identifying and addressing the major impediments to retention may be more appropriate than excluding patients with such impediments.
Clients mentioned absenteeism of health workers' behavioral issues as major impediments to positive interactions.
Necrotic and hypoxic conditions constitute major impediments to successful cancer therapy [ 10].
Lack of information and/or concerns about side effects were major impediments to DMARD use.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com