This difficulty is overcome by likelihood-based methods, allowing the estimate of distinct dN/dS ratios for each codon [24] [26].
If correct, such an approach will account for the physical mode of phosphorylation and will also overcome the statistical likelihood of false positive predictions based on single site predictions.
The problem of parallel deletions and insertions can be overcome using maximum likelihood methods by making use of transition probabilities [ 12].
In order to overcome this limitation, likelihood-free methods have also been considered e.g. [ 8], in which data are summarized by a set of statistics, and the likelihood is approximated by a distance metric between the observed summary statistics and summary statistics simulated from the model.
Banc of America said it met with Lockheed Chief Financial Officer Chris Kubasik Chris Kubasik, who had been very optimistic about the F-22, saying that the software issues had been overcome and that the likelihood that the company could regain some incentive fees on the program is improving.
That is, it takes especially strong evidence, in the form of extremely high values for ratios of likelihoods, to overcome the extremely low plausibility values possessed by some hypotheses.
Given the complexity of the historical and demographic models we aimed to explore, we sought to overcome the problem of unknown likelihood functions [38], [72] by using the ABC setting.
Dougherty et al. [ 12] implemented the normalized maximum likelihood model to overcome this issue.
Results will be used within a knowledge translation framework to identify any barriers to full implementation of bedside handover and to develop specific strategies to overcome them and increase the likelihood of uptake.
To overcome the fact that the likelihood of the emergence of a complex system by chance alone is low, Koonin's multiplies the universes where such a phenomenon could be observed.
We calculated breeding-failure equivalents in an analogous fashion to the calculation of lethal equivalents with maximum-likelihood [39] to overcome the problem of zero breeding success at one or more breeding levels.
