To overcome formulation-related issues, many people (healthcare practitioners, parents or patients) have to resort to manipulating the dosage form provided by, for instance, tablet cutting/splitting/crushing/mixing/dissolving [ 67, 68].
This review outlines SDLFs as one of the most promising approaches to overcome the formulation difficulties of these hydrophobic/lipophilic drugs.
Our results suggest that EIDD-1723 represents a substantial advantage over current PROG formulations because it overcomes storage, formulation and delivery limitations of PROG and can thereby reduce the time between injury and treatment.
These difficulties may be overcome through formulations aimed at improving CsA water solubility (e.g. cyclodextrins), or those designed to facilitate tissue drug penetration using penetration enhancers.
The imbalanced immune responses could be overcome by vaccine formulation, in particular formulated with a potent adjuvant [ 23].
But these formulations have some drawbacks, which can be overcome by formulating microsponges as shown in Table 1.
Another issue was the insolubility of the paclitaxel in water but these problems were eventually overcome with a formulation in ethanol and Cremophor EL.
Alternatives to liquid medicines are often sought where liquid medicines are not acceptable to patients; for example, where taste issues cannot be overcome, more sophisticated formulation approaches such as encapsulation of drug particles may be required.
An in vivo study of liposomal decitabine is recommended to assess its applicability for clinical use, and to confirm if the present limitations of decitabine use in the clinic could be overcome by this formulation.
