Sentence examples for overcome a requirement from inspiring English sources

Analysis of genetic interactions between BRM and the histone H2A.Z deposition machinery demonstrates that brm mutations overcome a requirement of H2A.Z for FLC activation suggesting that in the absence of BRM, a constitutively open chromatin conformation renders H2A.Z dispensable.

Intriguingly, the synergistic activation of the CCN2 promoter observed when Smad3 and Ets-1 were overexpressed together was not blocked by bisindolylmaleimide I, suggesting that the presence of Smad3 permits Ets-1 to overcome a requirement for PKC.

These results are consistent with the notion that Smads act to potentiate the activity of basal transcription factors [ 23], and suggest that Smad3 enables Ets-1 to overcome a requirement for PKC in the activation of target promoters.

In the case of Oklahoma, the threat of a school shutdown led to the first tax hike in nearly three decades, overcoming a supermajority requirement that three-quarters of lawmakers approve it.

Democrats are planning to use a parliamentary device known as reconciliation that would allow them to complete the process with a simple majority vote in the Senate rather than subjecting the bill to the 60-vote requirement to overcome a filibuster.

We propose that it is this higher binding affinity associated with ANTXR2 which overcomes an absolute requirement for an open-like configuration of the receptor I domain.

However, the requirement of 60 votes to overcome a filibuster is the true scandal.

That is, JAK2 V617F can overcome the requirement for a ligand-induced conformational change and effectively be capable of signaling from various relative conformations of a dimeric cytokine receptor, while in the wild-type scenario a ligand-induced conformational change in the receptor transmembrane and cytoplasmic domains is required, leading to the proper active conformation.

Moreover, activating mutations in the Ras or phosphoinositide 3-kinase (PI3K) pathway do not overcome the requirement of a functional p130Cas/FAK signalling complex for the survival and growth of human breast cancer cells [ 17].

Moreover, it would overcome the requirement to secure a normalizing signal under anoxia, since the Val E11 signal reaches its maximal intensity under oxygenated conditions.

With the number of adults and children living in a household at around twice the state average, extreme measures, potentially in breach of regulations, are sometimes used to overcome the requirement for every adult to hold a PNBC: "You see one of the things that happens they will place a child with a person that doesn't have approval under a safety plan.