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It's hardly surprising, given the mayhem and misery across the Middle East, that people who know and care about the region are scratching their heads trying to explain, never mind solve, its overarching problems.
Identifying errors and alternate conformers and modeling multiple main-chain conformers in poorly ordered regions are overarching problems in crystallographic structure determination that have limited automation efforts and structure quality.
But the overarching problems burdening not only the world's poor, but the earth itself will remain undaunted and unchecked.
Once you learn the overarching problems, like the three-year-old wanting some autonomy over his playtime or the teenager wanting to confess his alcoholism.
But these overarching problems are meaningless if no one cares to analyse them.
Privately and publicly, Mr. Obama has articulated what he sees as two overarching problems: coverage that focuses on political winners and losers rather than substance; and a "false balance," in which two opposing sides are given equal weight regardless of the facts.
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That, though, was the limit of Johnson's bravado, and this speaks to the Jets' overarching problem.
A classical approach to address complex problems is to break them down into more manageable sub-problems, solve these separately and then aggregate the results into a solution for the overarching problem.
I think the overarching problem with the U.S. health care system is that the economic incentives involved are misaligned, and that creates huge market failure so that market forces don't work effectively for patients, and that results in two major problems.
The second overarching problem was the policy framework.
While she took issue with how news outlets reported the hoax, the 24-year-old said it did manage to highlight the overarching problem and a put a public face to it.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com