There must be an overarching selective pressure that overrides such mutational, population genetic, and physical orientation forces (Race et al. 1999).
The theories result in a physically meaningful periodic table of virus capsids that uncovers strong and overarching evolutionary pressures, while also offering geometric explanations to other capsid properties (rigidity, pleomorphy, auxiliary requirements, etc).
Drivers of inappropriate prescribing include diagnostic uncertainty, lack of knowledge, unavailability of microbiologic support or infectious disease specialists, pharmaceutical marketing pressure, and the overarching fear of missing a life-threatening infection.
This overarching theme focuses on how high blood pressure and its treatment were framed from a patient and a healthcare professional perspective.
On the other hand, highly specific residue interactions may be under selective pressure to fit into an overarching architectural motif (such as helix-turn-helix motif), thus contributing to "long-range" feature dependencies.
A well-known example of their limitations occurred in the wake of the Challenger disaster when a focus on compromised O-rings (i.e., a failed, technical component) as the proximate cause of failure threatened to mask the overarching influence of powerful cost and timeline pressures on organisational scheduling and launch decision-making (e.g., Vaughn 1997).
Political pressures could slow the government's overarching strategy of achieving high-income status by 2020.
Her stewardship of individual parks has also been inconsistent, reflecting her attentiveness to local political pressures at the expense of an overarching national vision.
The overarching theme being monetization — or, more specifically, increasing external pressure to monetize these social services.
