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Our overarching hypothesis is that hypoxia not only makes tumor cells resistant to radiotherapy, chemotherapy and in some cases targeted therapy, but also increases their invasiveness and metastatic potential by inducing a select group of genes involved in tissue remodeling.
The study's overarching hypothesis is that treating insomnia will produce reduction in insomnia, PTSD, and depression severity, allowing patients to more fully engage in, and derive optimal benefits from, cognitive processing therapy.
The overarching hypothesis was that WNV primes astroglia to release S100B protein, which leads to a cascade of events that may have deleterious effects in both acute and chronic stages of WNV disease.
Therefore, the objective of this study was to investigate DSB induction by Cr VI) exposure with the overarching hypothesis that S phase-dependent DSBs are produced by Cr VI) exposure.
In this study we tested the overarching hypothesis that the angiogenic behaviours of leptin-stimulated human ECs depend upon COX-2 activity and require VEGFR2 activation.
Our overarching hypothesis is that spatial patterns of WNv in the northern Great Plains are determined by environmental drivers, and that these drivers have maintained a relatively stable zone of elevated WNv risk in the northern Great Plains.
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It would be interesting to use Mean Genes to foster a discussion of how to relate and balance different types of scientific evidence and whether they support overarching hypotheses.
The goal in the end is to present the lines of reasoning for (not to prove or disprove) each account, based on the science and integration of the lines of evidence, so that the data will speak for themselves in support ing (or not supporting) the overarching hypotheses that have been put forth.
The study of brain evolution is still in the stamp-collecting phase that begins most branches of science, when researchers are looking for interesting facts to stick in their albums, rather than assembling overarching hypotheses.
We will examine the following overarching hypotheses in the sub-cohort recruited from WH II Phase 11: (1) Early risk factors for cognitive dysfunction and late onset depression (such as cardio-vascular risk, see (i). to (v).
This is because evolution operates as an overarching theory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com