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Ethical principles such as autonomy, beneficence, nonmaleficence and justice [ 1] are useful for both researchers and participants in a clinical trial as an overarching frame of reference.
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"Our frame of reference changes.
His frame of reference is himself.
Her frame of reference can seem narrow.
They had broadened his frame of reference.
"You have no frame of reference".
"That was our frame of reference.
The sonic frame of reference shifted.
Their frame of reference is narrow.
But the frame of reference changes.
The frame of reference is the schedule.
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