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For a further 17, we were able to amplify across at least one junction, giving an overall verification rate of 42/45 tumour inserts (93 %).
Table 5 gives the results for the scenarios in the bottom half of table 2, where the number of false negatives is higher when the overall verification rate is lower.
To test whether small cell counts or overall verification rates drove our findings, we repeated our simulations using probabilities of verification as shown in the bottom half of table 2: in this case, the probability of small numbers of false negatives is higher in the scenario with a higher overall verification rate.
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Rangachari's noise tracking algorithm gave the worst overall verification performance.
The base verification rate (VR) is 0.98 at a false accept rate (FAR) of 0.001.
This verification rate is in accordance with previous studies [19].
The core data set (966 IRs; 943 PPIs) displays a verification rate of 70%.
In this study, the histological verification rate was 99.8%.
To minimize false-positives, verification resequencing is necessary to estimate the technology-relevant errors, and it is important for studies to report a verification rate.
Our study is based on singular value decomposition (SVD) and AraCyc metabolic pathways for overall verification of gene co-expressions.
Figure 3 Best verification rates reported during the FRVT 2006.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com