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Overall the alterations in the metabolome detected in this study as associated with PCa bone metastases indicated disturbed molecular and cellular functions of clear relevance for cancer progression.
Overall the alterations occurring in microgravity have undoubtedly significant backwashes on the physiological homeostasis of the whole organism.
Overall, the alterations in lipid metabolites induced with treatment suggest additional anti-cancer activity associated with NSC-134754 in vitro.
Overall, the alterations in endogenous hormone levels following uniconazole treatment improved starch accumulation in duckweed by influencing the related enzymes involved in carbohydrate metabolism and processes.
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Overall these alterations may serve to facilitate the potential survival of gonadal tissue in the males.
While the overall direction of the alterations in CA1 excitability, represented by the enhanced field responses, was in general agreement with what could be expected from homeostatic plasticity, the specific alterations in synaptic properties presented a considerably more complex picture.
In the study of ethyl acetate extracts from brown algae Colpomenia sinuosa[ 31], the research focused on the sub-G1 phase as an indication of apoptosis without further exploring the overall alterations in the cell cycle.
Thus, while the changes were more dramatic in the mPrE-γ2sh cells, the overall ultrastructural alterations were reminiscent of the cytoplasmic changes noted in the prostatic epithelium from PPARγKO mice and were consistent with increased autophagocytosis (autophagy).
Overall, these alterations favor an undifferentiated cellular phenotype.
Overall, the cell cycle alterations observed with Titanocenes X and Y differ from that observed following cisplatin treatment in A431 cells, and suggests that cisplatin and Titanocene compounds initiate their apoptotic effects via alternative mechanisms.
The overall alterations including metabolites highlighted as contributing to the significant separations in the models reported above are summarized in Table S2.
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