On a typical day, Abedin is gathering policy updates, working through the nuts-and-bolts of a grueling campaign schedule, and serving as an overall surrogate and adviser.
This study investigates the differences between using a non-linear global surrogate model (namely, least-squares support vector machines) and a linear piece-wise surrogate model (namely, linear nearest neighbour interpolation), as well as the use of sequential sampling algorithm as a means of improving overall surrogate accuracy.
The Pentagon considered this an important Coalition military strategy - part of its overall surrogate strategy to lay the groundwork for an offensive and ultimate liberation of ISIS's capital of Raqqa.
Another study showed an overall surrogate positive predictive value for a high-risk scenario of 79.7% [ 25].
The investigators found that the overall surrogate positive predictive value for a low-risk study was 84.0% and for a high-risk study it was 79.7%.
Overall, the surrogates can be seen as providing a discovery continuum by bridging the gap between functional genomics and proteomics and modern drug discovery.
Once all recommendations were categorized, descriptive statistics were performed, to identify characteristics associated with surrogates overall and with accepted versus non-accepted surrogates.
To substitute to a clinical endpoint such as progression free or overall survival, a surrogate endpoint has to be shown to be highly correlated with the clinical endpoint in a series of coordinated prospectively designed multi-centre trials culminating in a formal meta-analysis [11].
Therefore, DP can surrogate overall survival, thus shortening the duration of clinical studies in CLL.
A more recent GWAS meta-analysis took a unique approach to studying aging by considering overall 'wellness', a surrogate for health span, based on the concept that successful aging would be related to broad resistance to disease (Jeck et al., 2012).
