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No significant changes in overall skin condition were observed from weeks 3 to 6.
However, the indoor environment possibly contributed to the overall skin condition.
This might have offset overall skin condition results favorably but did most likely not change trends over time.
Assessment of skin softness, smoothness, dryness, and overall skin condition was very good at baseline and remained so with minimal changes throughout the study.
This additional improvement in clinical grading scores for hyperpigmentation at 12 weeks over the first application is the apparent result of the cumulative effect of key ingredients on the overall skin condition.
Subjects were excluded from participating in the studies if they had a dermatological evaluation score >0.5 for all parameters on the 4-point clinical grading scale (for rash, skin irritation, or other skin conditions [study 1]) or moderate-to-severe score (≥2.0 for all parameters on the 4-point clinical grading scale) for erythema, dryness, rash, or overall skin condition at baseline (study 2).
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Both investigators and owners agreed that concurrent therapy resulted in a quicker improvement of the dogs 'overall' skin condition and of pruritus (significant reduction of pruritus by day 3 4, 72.8% improvement by day 14 ± 1), when compared to cyclosporine A alone (significant reduction of pruritus by day 7 8, 24.7% improvement by day 14 ± 1).
There was a significant improvement in all parameters after single application of the test baby lotion, but the clinical significance is not clear because the overall change was minimal as a result of the good skin condition at baseline.
At week 3, mothers reported significant improvements versus baseline (P ≤ 0.05) in skin condition indices (including skin moisturization, softness, smoothness, and overall condition/appearance) on the arms.
Skin cues such as overall skin colour and colour homogeneity, for example, are observable, objectively measurable, and known correlates of condition in humans and non-human animals [38], [40], [41].
Skin moisturization, softness, smoothness, and overall skin condition/appearance were graded on a scale from 1 to 10; an increase in score indicated a relative improvement in skin condition (Table 2).
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