Sentence examples for overall mutations from inspiring English sources

Overall, mutations in NRAS and SMAD4 were stable in one case each, while genes mutated in more than one study case (KRAS and BRAF) showed different patterns of stability/instability for distinct variants (BRAF V600E vs. G469V, KRAS G12R vs. G12V) and even for the same variant (KRAS G12V).> -wrap-foot> *Only those mutations observed by two independent technologies (true positives) included.

As with overall mutations, neither PY nor smoking status had any significant effect in this model.

Overall, mutations in moderate-penetrance genes account for less than 3% of the familial risk of breast cancer.

The rate of mutation in exon 19 is the highest, accounting for more than 60% of overall mutations.

Overall, mutations were more common in borderline lesions (35%) than in primary carcinoma (16%) and recurrent ovarian carcinoma (6%).

Overall, mutations in NRAS were found in 3%% of samples, in BRAF in 8 %, and in PIK3CA in 9 %.

Likewise, our melanoma hypermethylated group MS1 was not significantly associated with a mutated gene or overall mutation rate.

The luminal subtypes, on the other hand, are reported as heterogeneous, with the largest number of mutated genes but low overall mutation rates [ 5].

MTMMs were mapped to the individual tumor SAMMs to determine the maximum contribution of each mutational mechanism to the overall mutation pattern.

First, mutational profiles have lower statistical support in genomes that have low overall mutation rate.

Therefore, an overall mutation rate is 1.10% for LATS1 and 0.84% for LATS2.