Pendrin was clearly demonstrated by means of immunohistochemic method in 73.3% of FTCs and 76.7% of PTCs with overall intracellular localisation.
In addition, consistent with previous findings, loss of Rb binding through expression of the HPV-E7 protein also decreased the overall nuclear localisation of endogenous BAG-1 protein in colorectal adenoma-derived cells.
Hence, we conclude that there is no significant change in the overall expression and localisation of the FGFR3 in human prostate cancer.
To further explore the relationship between the levels of S100A6 and membranous annexin 2, we examined whether diminishing the levels of S100A6 in a pancreatic cancer cell line would affect the overall levels or localisation of annexin 2. After siRNA-mediated depletion of S100A6 from Panc-1 cells, the overall levels of annexin 2 appeared unchanged.
Overall, such 'detection without localisation' occurred on a very small number of trials (~ 4), precluding statistical analysis, which means we have only the numerical difference to support any such inference.
They affect the activity, localisation and overall function of other proteins by adding a phosphate group and thereby control the activity of cellular processes.
Display propensity, overall expression and soluble localisation to the periplasm and extracellular fractions were clone specific characteristics which varied despite high levels of sequence homology.
In addition, it has been reported that the overall pattern of BubR1 localisation, revealed by immunostaining, differed between normal and malignant tissues in bladder, colon, pancreas, and skin cancers (Shin et al, 2003; Yamamoto et al, 2007; Burum-Auensen et al, 2007b).
In gastro-oesophageal cancers previously exposed to neoadjuvant chemotherapy, 34.8% (16 out of 46) of tumours were positive in the nucleus and this correlated with shorter overall survival (P=0.005), whereas cytoplasmic localisation correlated with tumour dedifferentiation (P=0.034).
Studies comparing preoperative elastograms with whole-mount step sections after RPE showed a sensitivity of 50 87%, a specificity of 72 92% for correct PCa localisation, and an overall PPV of 67 88% and a NPV of 44 83% [ 33– 33].
