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For each overlapping PFM starting at the first position of each of the 3 or 5 nt sliding window, we systematically kept the most informative one, maximizing the overall information content of the sequence.
Composite scale sensitivity (CSS) can reveal the overall information content of the data.
Because the bulk physical properties of compounds are known to correlate with each other to some extent, Hopkins and colleagues used different property weightings to maximize the overall information content of the combined QED values for each drug.
Further, analyses based on haplotypes can outperform single-point analyses in which multiple SNPs in a gene are interrogated one at a time, because haplotypes can increase the overall information content at a given locus [15] and potentially capture association signals from variants that have not been directly typed [16].
Therefore, the overall information content of the expression data is low with respect to the phenotype.
As expected we found an overrepresentation of A and T bases, as they make up around 70%% of the targeted bases (Fig. 2), resulting in an overall information content of less than 0.5 at the central position.
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Heteroplasmy not only has the potential to put extra weight on haplotypes by increasing the overall (forensic) information content of a particular haplotype [11], but also plays a paramount role for mtDNA evolution as well as the understanding and diagnosis of mitochondrial diseases.
Mutual Information MII) [ 19] is an adequate measure to estimate the overall diagnostic information content of single biomarkers [ 22].
The overall polymorphism information content (PIC) value varied from 0.11 to 0.72 with an average of 0.4 (Table 5).
The overall polymorphism information content (PIC) index of each locus, after standardization for the number of alleles [ 30], was also plotted on the durum consensus map.
Overall, the phenotypic information content is higher for Neuroticism than for Extraversion in most cohorts, suggesting more power to find loci for Neuroticism than for Extraversion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com