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In another study of 111 percutaneous image-guided peritoneal and omental biopsies, the overall diagnostic rate was 89%, with a sensitivity of 93% and specificity of 86% [26].
Overall diagnostic rate was 88.5%.
The overall diagnostic rate was 71%.
Accordingly, the overall diagnostic rate by bronchoscopy was 93.4%.
The overall diagnostic rate of CNB was 88.5% including first and repeated biopsies; sensitivity and specificity were 85.9% and 100%, respectively.
As all variants detected by Sanger sequencing were covered in our WES data, if our molecular genetic approach was modified to WES followed by targeted CNV analysis, the overall diagnostic rate would approach 76%.
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In chromosomal studies by G-band method (Fig. 2B), overall diagnostic rates of CNB and surgery, 58.8% (20/34) and 80% (8/10) (P = 0.406) and ratios for detecting any chromosomal abnormalities related to lymphoid malignancies, 32% (12/38) and 41.3% (7/17) (P = 0.226), did not differ significantly between the groups.
Ballpark estimates place the overall diagnostic error rate in the range of 10 15%.
The overall diagnostic misclassification rate was 9.2%9595% CI: 6.9-11.9); when the malformation was screened during the second trimester and the specialized follow-up ultrasound performed between 20-30 weeks, it was 10.8% (95% CI: 7.7-14.6), and when screening took place during the third trimester and the specialized follow-up ultrasound after 30 weeks, 6.3%9595% CI: 3.3-10.7).
We hypothesise therefore that the observed change in presenting PSA levels is probably due to a greater awareness of prostate cancer and uptake of opportunistic testing, which has driven both the overall rise in diagnostic rates and increased detection at lower PSA levels.
The overall diagnostic accuracy of 'triple' assessment is 99.6% and the 'missed' cancer rate is 1.7 per 1000 women discharged.
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