Sentence examples for overall destabilization from inspiring English sources

However, this action implies structural changes that may result in an overall destabilization of the closed-loop system.

We have switched from a Taylorist rationality based on Scientific Management, which claimed to fit production into a single viewpoint, to a dissemination of the sources of the directions to be followed and an overall destabilization of any attempt at rationalization, and as a consequence, to a looser sense of rationality even among engineers.

By using distal (Y25A) and proximal (K56A) face mutants, a large overall destabilization in affinities were observed for fhlA binding to Hfq.

Melting temperatures (Tm) were consistently (52±2 °CC (data not shown), thus suggesting that a lack of flavin cofactor does not lead to an overall destabilization of OhyA.

This can be due to unmasking of certain sites buried at the subunit interface or due to the overall destabilization of the structure.

Based on our predictive model, all these missense mutations affect surface-exposed residues, causing overall destabilization of the molecule (Fig.  2A and B).

The correlation between M-phase accumulation and TP53 mutant status that we observed is consistent with this overall model: Destabilization of mutant p53 combined with the corresponding loss of p21 activity and the subsequent weakening of G1/S and G2/M checkpoint surveillance could permit cells to inappropriately enter M, as would destabilization of WEE1 and CHK1.

We considered the possibility that Asp substitutions of the Lys residues in the D5 mutant led to overall protein destabilization and denaturation.

This may be important, since the crystal structure of GAD67 reveals that Val packs tightly against the catalytic loop (Supplementary Figure S1C) and we reasoned that substitution of this residue with a larger leucine residue may significantly contribute to destabilization of the overall catalytic loop structure.

Consistent with this possibility, the overall balance of microtubule-associated proteins, destabilizing factors, and inhibitors of microtubule assembly suggest an increased destabilization of microtubule assembly, which is potentially linked to an increase in the stability of cell structure and a decreased ability to initiate neurite extension.

Sleep then reconsolidated the destabilized memories, and the observed cycle of use-dependent destabilization and sleep-dependent reconsolidation repeated across multiple days even as overall task performance improved.