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The stronger negative selection acting on the nucleotide content of protein coding sequences provides additional evidence to support the proposal that minimal introns in a size range of 50 86 nt are more likely to subject to purifying selection resisting to the overall deletion force acting in all introns.
Overall, deletion of pyruvate formate-lyase (PFL) was the most frequent for all of the approaches.
Since this was observed for 2 elements only, we believe that this process does not affect tremendously our conclusions on the overall deletion process.
Hemizygous deletion was found in 35 (15.1%) tumour samples and homozygous deletion was identified in 17 (7.3%) carcinomas resulting in an overall deletion rate of 22.4% (n=52).
These findings are compatible with the observation of the overall deletion bias in the evolution of prokaryotic (as well as eukaryotic) genomes [ 32, 33].
‡ bold, WT sequence; underlined, ITD; lower case, N nucleotides *1073 had an 11 bp deletion with a 2 bp insertion, giving an overall deletion of 9 bp.
Similar(54)
Results Overall, DD (deletion-deletion) homozygotes had a higher restenosis risk than II (insertion-insertion) carriers (odds ratio 1.22, 95% CI 1.04-1.44, P <.05).
The relation of amount of deletions detected per pool and the amount of overall detected deletion for the Poisson model and VarScan, suggest a large overlap of deletions found in all four pools.
Overall the deletion frequency was evenly distributed and no significant difference was observed among the bins.
Overall, Atp6ap2 deletion in glutamatergic neurons induced substantial deficits in both cued and contextual fear conditioning, suggesting altered emotional learning and memory.
Overall, gene deletion or movement may appear as a particularly active phenomenon after polyploidy and may then act preferentially on the sensitive genome compartments, making them more labile than the orthologous dominant counterpart.
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