Sentence examples for overall defect from inspiring English sources

ATGL-deficient mice suffer from an overall defect in energy homeostasis, defective thermogenesis, and severe cardiomyopathy, the latter leading to premature death of the animals [1].

Taken together with the appearance of polyubiquitin aggregates, these data are consistent with an overall defect in autophagic clearance of proteins and defective organelles.

Dyslexia represents a difficulty with reading, she says, not with thinking skills, one that "does not reflect an overall defect in language," but rather a weakness in a part of the language system.

For hydrogels that contained BMP-2, similar volumes of new bone tissue were formed; however, the faster degrading hydrogel exhibited improved cellular invasion, bone volume to total volume ratio, and overall defect filling.

RuO4 and KMnO4 resulted in similar amounts of overall defect sites, however the yield and amount of –COOH groups for KMnO4 treated CNF were significantly lower than the RuO4 treatment.

But it has the overall defect of condemning participants to a shakier retirement.

The overall defects were rather similar to the Hsp/DNAj system, suggesting that this is a phenotype associated with disruption of ER protein folding.

The overall defects in the homozygous DAT-KO mice have made it less suitable to probe the role of dopamine in regulating memory processes.

If so, this might explain why only 31% of defects in cytosolic protein homeostasis resulted in overall defects in behaviour or development in comparison to 48% of defects in sarcomeres.

To determine the overall defects of Runx1-null luminal MECs, we first profiled the transcriptomes of YFP+ Runx1-null luminal cells (sorted from MMTV-Cre Runx1 MMTV-Cre Runx1L/L) and contR26YYfemalesx1-wild-type (WT) luminandcontrolsorted from MMTV-Cre;Runx1 +/+ ;R26YFP+y microarray.

This effect was specific to axon branching defects, as overall pathfinding defects (axons that wander, or that stop short of the dorsal nerve cord) remained unchanged.