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Overall, compound 10d could be a promising candidate and a good starting point as anticancer drugs.
Overall compound 9 appeared the most promising compound being a potent and long-lasting P-gp dependent MDR modulator.
Overall, compound 74 exhibited potent anti-parasitic activity (IC50 = 0.9 ± 0.1 μM), corresponding with its inhibitory activity against falcipain-2, with a Ki of 1.1 ± 0.1 μM.
Overall, compound 7, a potent and selective dual AChEI, can be considered as a candidate with potential impact for further pharmacological development in Alzheimer's therapy.
Overall, compound A2 was the only one with a detectable inhibitory potential of COX-2 activity whilst two of its ether derivatives demonstrated improved ability in the inhibition of COX-2 expression.
Overall, compound 19 represents a new class of Hsp90 inhibitor with its 6,7-dihydrothieno[3,2-c]pyridin-5(4H -yl-amide structure, and it has the therapeutic potential to overcome drug resistance in cancer chemotherapy.
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Among the overall compounds of great importance, Ag NPs are used as antimicrobial in hydrocolloids, alginates, and hydrofibrous materials fabricated by electrospinning [142].
Overall, compounds 13a and 13b, 13b in particular, standed out from various assessments and might be promising candidates for further chemical optimization.
Overall, compounds having three 2,6-disubstituted pyridine units separated by at least one C2- or C3-linker displayed the most potent inhibition of Aβ aggregation.
Overall, compounds that are inhibitors of MRP7 transport activity attenuate or reverse resistance in cancer cells that express the MRP7 protein.
This overall compound-flow looks reasonable for an ideal metabolism of a living cell.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com