In human the 5′SS sequences processed by major spliceosomes are degenerate but show significant overall complementarity to the sequence of the 5′ end of U1 snRNA (Lerner et al., 1980).
Our finding that the length of seed complementarity affects CODEMIR activity independent of overall complementarity is surprising given the current understanding of microRNA-target interactions [ 4, 9, 11].
Thus, the length of seed complementarity, and overall complementarity between the guide strand and the target should be considered in the design of multi-target interfering RNAs.
However, because the balance of prioritization between the two goals determines the range of potential shared benefits and overall complementarity, management may not meet multiple goals unless it is explicitly designed to do so.
Overall, complementarity theory suggests that high performing firms are likely to combine a consistent set of activities and that the returns to such full configuration of activities are greater than the sum of the individual returns (Whittington et al. 1999).
During recent years, a number of prediction algorithms have been developed to track miRNA targeting based on seed pairing, overall complementarity, pairing stability, target site evolutionary conservation and UTR context.
In addition to the overall shape complementarity, the number of local intermolecular hydrogen bonds observed between the kinase antigens and the residues from the antigen-recognition sites provide a high degree of epitope discrimination and specificities (Supplementary Figures S3B and S3D).
Using patent data from 1968 to 2002 in the semiconductor industry, we find that the overall level of complementarity between knowledge components positively contributes to firms' inventive capability, whereas the overall level of substitutability between knowledge components generally has the opposite effect.
In addition, mixtures of SCMSV peptide standards to assess overall capabilities of stationary phases to resolve complex peptide mixtures underlined the useful complementarity of combinations of different columns and elution conditions to maximize flexibility in peptide applications.
However, an overall negative complementarity effect also contributed to the net effect of diversity, indicating the presence of negative (interference and/or exploitative) competition [57], [58] in the species mixture.
