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The compartmental in silico model was successful in describing the pulmonary drug transport profiles of the investigated compounds and has potential for further development to investigate the effects of formulations with different features on the pulmonary overall absorption rate.
Part I of this paper deals with the case of equal diffusivities of the chemical species involved whereas the effect of unequal diffusivities on the overall absorption rate and enhancement will be dealt with in Part II.
The reaction rate constant for water is higher in the SARMAPA system than in amine systems indicating that water contributes significantly to the overall absorption rate and more than in amine systems.
This spreading of digestion process delays the overall absorption rate of glucose into the blood.
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Depending on the length of the contact time between the gas and the liquid, the assumption of an instantaneous hydrolysis reaction has an impact on the overall SO2 absorption rate.
From the measured CO2 concentrations at the outlet, the absorption rate and overall mass-transfer coefficient can be determined with the support of a steady-state material balance, as well as a two-film model.
Diethanolamine (DEA) and 2-Amino-2-methyl-1-propanol (AMP) are found to have the best overall performances in terms of CO2 absorption rate at lean loading and cyclic capacity in mol CO2/mol absorbent.
The release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extended-release formulations.
In Part II, the effect of unequal diffusivity on the absorption rate and, hence, the overall enhancement factor in consecutive reaction systems has been presented in detail.
Similarly, delaying gastric emptying may decrease the rate at which the drug enters the small bowel, thus preventing saturation of absorptive mechanisms and increasing overall absorption (18 ).
The responses, including absorption efficiency (E), absorption rate (RA), scrubbing factor, and overall mass transfer coefficient (KGa) were determined by material balance with a two-film model at a steady-state condition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com