Braced by harmony, bludgeoned by decoration the dream surgeon hobbles three steps over, two steps beside.
The yield of 1 over two steps was in excess of 78%.
Results: Precursor for radiolabeling was prepared in 45% yield over two steps.
(I) K2CO3, H2O, Br2, 0 °C to rt. (II) a TBDMSCl, imidazole, DMAP, DMF, 0 °C to rt, 75%% over two steps for 4a to 8a through 7a; 4b to 8b through 7b; b 2,4,6-tris(benzyloxy -1,3,5-triazine, TfOH, dioxane, 0 °C to rt, 65 % over two steps for 4a to 8c through 7a; c TIPSOTf, lutidine, DMAP, DMF, 0 °C to rt, 70 % over two steps for 4a to 8d through 7a.
After reductive aminocyclization with DABAL-H and debenzylation with metal lithium in liquid ammonia (Scheme 11), intermediate 31 was obtained in 49 % yield over two steps.
The reaction mixture was concentrated under reduced pressure and washed with diethyl ether to afford 140 mg (68 % over two steps) of a gray powder after drying.
The numerical formula is derived by integration over two steps, where the integrals of terms on the right-hand side of (1) are approximated via the trapezoidal rule and the midpoint rule, respectively.
The SLACC is obtained over two steps: (i) calculating the correlation between a slope patch and a defined surrounding area and (ii) identifying the characteristic length of correlation for each neighbourhood.
Yield (42 mg, 79% over two steps).
Yields were generally >80%% over two steps.
Yield: 5 mg (8% over two steps).
