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However, there is a potential risk for psychiatric de-stabilization, even with a careful cross-over titration.
We recognize that antipsychotic switch assignment has a risk of de-stabilizing psychiatric symptoms, however our protocol allows for a gradual cross-over titration and flexible dosing to minimize adverse events during the medication switch.
The methylation of a capped RNA substrate was measured over a time course and over a titration of immunoprecipitated HA RNMT protein.
In comparison with titration over 1 week, titration over 4 6 weeks appears to reduce the frequency of adverse events (Anon. 2005a).
Significant pH corrections were required over the titration as the lyophilized protein is acidic.
The change in the serum phosphorus level at each visit over the titration period was examined.
Before all anisotropy measurements, the emission spectra of PIP2-C6∗ (550 to 650 nm) were inspected monitoring signal/noise ratio quality and eventual spectral changes over protein titration.
In any given solvent mixture, the δ value is constant over normal titration ranges ("neither very high, nor very low"(20)).
Over the titration period, 157 AEs were reported by 90 of 258 (34.9%) patients enrolled in the study; of these, 101 AEs reported by 40 patients (34.9%) were considered related to experimental drugs.
Both doses were significantly more effective compared with placebo over the titration (P = 0.03, P = 0.006), maintenance (P = 0.01, P = 0.005), and entire treatment periods (P = 0.03, P = 0.02).
The existence of a stable single-head interacting intermediate of the chimera before ATP addition was confirmed by titration over a huge range of microtubule concentrations (Figure 4B).
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