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Therefore, a new Leader needs to request the flushed LSN to the Followers when it starts to take over the replication.
One possible advantage of the primary discovery ADHD sample used to derive risk alleles, over the replication sample, is its similarity to the ALSPAC cohort in terms of ancestry and geography, but nevertheless the sample was relatively small (4).
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Once replication is over and the replication checkpoint is turned off, HR centers can be assembled to complete the repair of the accumulated ssDNA gaps and broken ends.
Each scenario was simulated for 15 years and replicated 10 times, with results averaged over the replications.
Because the training and prediction sets produced over the replications are always drawn from the same data set, the replications are not independent.
Estimation of marker effects in the simulated data set was replicated 50 times for each GWP approach and the estimated effects sizes for each marker were averaged over the replications.
For independent validation, we derived a final consensus model consisting of the SNPs selected in >60 % of the replications, with corresponding weights being the average weights over the replications (the final risk scores are given in Additional files 2 and 3).
These are the number of tissues (22), the number of replications per tissue (three to five), the total number of expression values for a gene (70), the SD per tissue calculated over the replications (s=0.04, corresponding to the median SD in the data) and the overall mean expression level (μ = 7.3).
Pavlov proposed a model where Pol ɛ starts replicating the leading strand, but may later dissociate, and Pol δ then takes over to complete the replication [ 8].
A virus take over of the replication apparatus could have created a bacterium with a novel replication apparatus, that's all.
As shown in Supplementary Fig. 3, there was marked over-representation in the 'Replication, recombination, and repair' category in M. aeruginosa, due to the presence of a large number of transposase genes, as described in Section 3.3.1.
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