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Due to p53 mediated apoptosis, cells with DNA damage, D≫1 will be removed from population and thus the average of the assigned DNA damage, μ D will differ from the actual average DNA damage, 〈 D〉, averaged over replicating cells.
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The performance of the proposed HDLA model is then evaluated in comparison with Over Replicated Softmax Model (ORS M.
We took as the detection p-value the maximum for each probe set over replicates as a conservative estimate of detection.
The data taken from references [ 36] and [ 37] are averaged values over replicated experiments.
Forty-eight lactating Holstein cows were subjected to each of 2 treatments in a 2 × 2 cross-over design replicated over time.
One mutation causes over-replication, giving rise to a clone, which further over-replicates due to a second mutation, etc.
Plasmids that systematically over-replicate relative to their cell mates have a higher chance of fixing in a cell (intra-host selection).
For example, the virulent wMelPop strain appears to over-replicate at elevated temperatures [ 59].
Structure provided consistent results over 10 replicated runs tested for each K and over the different models tested (see Methods).
The process can be repeated over replicates to develop a robust estimate of peak reaction efficiency.
In all these experiments, the performance of the proposed model is compared with the following baseline approaches such as Over Replicated Softmax Model (ORSM) [21], Replicated Softmax Model (RS M [6] and Rate Adapting Poisson model (RAP) [5].
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