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"We really have to get control over multiple pregnancies, and we are trying," Dr. Marrs said.
Although a history of postpartum hemorrhage (PPH) is a recognized risk factor for PPH in subsequent pregnancies, little is known about how the risk accumulates over multiple pregnancies, how recurrence varies by PPH subtype, and whether recurrence can be explained by chronic maternal conditions.
Given that the Runx2 transgene shows a mosaic pattern of expression, one possible explanation is that parity-induced progenitor cells expressing the transgene have a selective disadvantage and are outcompeted over multiple pregnancies, with ultimate recovery of function.
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In the UK over 70% of multiple pregnancies are delivered by caesarean section, which leads to a longer recovery time.
Although in vitro fertilization (IVF) success rates have improved over the past decade, multiple pregnancies have become a formidable problem.
An increase of pre- and postnatally diagnosed DS cases at present is caused by several demographic and medical factors, such as by an increase of mean maternal age in the country along with increasing proportion of mothers 35 years of age old and over and increased number of multiple pregnancies.
Thirdly, the HIPE database lacks unique maternal identifiers, and therefore we were unable to link deliveries for women who had multiple pregnancies over the study period.
These previous analyses demonstrated the economic merit of Option B+, and our analysis extends these findings by incorporating the possibility of multiple pregnancies over a woman's lifetime, and including primary data collection from antenatal clinics.
This would suggest that in vitro fertilisation with single embryo transfer or in vitro fertilisation in a modified natural cycle has no benefit in the reduction of multiple pregnancies over intrauterine insemination with controlled ovarian hyperstimulation.
Risk factors for the development of preeclampsia and eclampsia are overweight, hypertension, age over 40, diabetes, kidney disease, and multiple pregnancies.
The relationship between maternal morbidities and multiple pregnancies may also differ, potentially leading to over-estimates of effect.
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