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The CEIO-NPs were chemically oxidized and surface modified with PEG FA for selective tumor localization in cancer cells that over expresses the folate receptors (FR+).
We next tested whether cells expressing a mutant miR-24-target site allele (C→T) that over expresses DHFR provides cells with a growth advantage.
The act1++ line is a transgenic line that over expresses GPAT (i.e., the act1 gene product).
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Late in the film, Khan, in a voice-over, expresses anger at this cruel imbalance: "How could you not remember abusing me every day in that house?
This difference is in accordance to the degree of AcrAB efflux pump expression, namely the AG100TET over-expresses this pump 6-fold over that of AG100, as shown by real-time quantitative reverse transcriptase-PCR (qRT-PCR) [5].
However, its aberrant expression, in which p16INK4a not only over-expresses but also changes its subcellular distribution from nuclear to cytoplasmic, has also been found in some types of cancer, especially in precancerous cervical lesions and cancers [ 42].
One of the most sensitive cell lines, melanoma derived SK-Mel-5, over-expresses the iron efflux transporter ferroportin and has decreased expression of proteins involved in iron uptake, suggesting that it actively suppresses cytoplasmic iron.
In vivo, on treatment with H2O2, the recombinant AnC56S+ strain (that over-expresses Alr4641C56S) showed higher ROS levels compared to the An4641+ strain (that over-expresses the wild-type Alr4641).
Sometimes when coral is moderately stressed, it over-expresses some of its colour pigments, glowing in unusually rich colours, in what's known as "fluorescing".
This approach was tested in the human KB cell line, which over-expresses both folate receptor (FR) and the epidermal growth factor receptor (EGFR).
Moreover, the target compounds exhibited considerable cytotoxic activity against cervical cancer cell line HeLa that over-expresses p110α (0.21–1.99 μM).
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