Sentence examples for over duplication from inspiring English sources
However, the global effect following CDK11 RNAi was a centriole duplication defect and not an over duplication as expected in case of Plk4 overexpression.
A noticeable decrease was observed in Plk4 and CDK11-depleted cells, with a percentage of cells displaying more than two centrosomes of 9.0±2.1% and 11.9±1.7% respectively, indicating a ∼3-fold inhibition of the spontaneous centriole over duplication process observed in U2OS control cells.
The dominance of gene contraction over duplication was obvious when the aCGH selection ratio was relaxed (data not shown).
As well as ciliation defects, RNAi depletion of Poc1 in cultured human cells caused a reduction in centriole number in an over-duplication assay, whereas over-expression induced aberrant elongation of the centriolar central microtubule structure [6], and antibody injection disrupted cell division [8].
Aberrant accumulation of β-catenin in the centrosome during G1/S causes centriole splitting and centriole over-duplication [ 7, 9].
Our results show SPATA4 has similar phenotypes to PIFO mutant cells including centrosome over-duplication and cell-cycle arrest.
Centrosomal DNA-PK signaling triggers the accumulation of β-catenin, leading to centrosome over-duplication and centriole splitting.
The expression of HsMCM5 or its cyclin E-interacting domain significantly inhibits over-duplication of centrosomes indicating that proteins involved in DNA replication might also regulate centrosome duplication.
Similarly, CDT1 promotes microtubule attachment to kinetochores [80], whilst the CDT1 inhibitor, geminin, is involved in preventing centrosome over-duplication [73].
Once SF-1 is depleted, DNA-PKcs is recruited to the centrosome forming an active complex with Ku subunits to phosphorylate downstream Akt; this signaling cascade induces centriole over-duplication.
Aberrant accumulation of β-catenin in the centrosome during G1/S phase causes centriole splitting to a distance of more than 2 μm between two centrioles; it also causes centriole over-duplication [ 7, 9].
