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We found that the minimum effective population size Nemin such that selection against BRCA1 mutations dominates over drift is 92 (s = 0.0541) for Quebec populations, 60 (s = 0.0833) for Ache populations and 130 (s = 0.0382) for the modeled population.
Our results therefore advocate for a dominant role of selection over drift despite small effective population sizes.
When Ne is large, like in Drosophila, selection dominates over drift, but any factor that decreases Ne (e.g., bottleneck, mating system) will strengthen drift.
Although we cannot completely rule out the possibility of allele frequency differences caused by drift or admixture, the finding that there is statistically significant agreement between chromosomal regions having large allele frequency differences with QTL regions provides independent evidence for selection over drift, which is a random process.
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