Exact(14)
These microenvironments determine stem cell fate via control over differentiation.
These RNAs are drastically regulated over differentiation.
Ap2 promotes proliferation over differentiation and is a marker of SC and pluripotency [32].
Therefore, the 146 predicted microRNAs selected by Ago2 IP are found to be regulated over differentiation as predicted, but in patterns similar to those of known microRNAs.
Finally, the discovery that OS differentiation can not only be suppressed by depolarization, but can also be augmented with hyperpolarization, strongly suggests that the Vmem exerts specific control over differentiation events.
Additional support for self-renewal in the prostate stem cell niche is indicated by Ap2 (Table 1) that promotes proliferation over differentiation and is a marker of stemness and pluripotency [38].
Similar(46)
Conditional loss of CFL1 in neuronal cells causes over-differentiation, altered proliferation, and migration that are linked to a lissencephaly phenotype (Bellenchi et al., 2007).
About half (9 of 14 tested) of the mus304 D3 animals show lymph gland enlargement, which was often accompanied (6 of 9) by lamellocyte over-differentiation in one or both primary lobes.
Therefore, in addition to avoiding dedifferentiation and unrestricted tumorigenic overproliferation, INPs need to overcome another challenge to avoid over-differentiation and cell cycle exit in order to maintain their progenitor state and self-renewal while they differentiate to mature and undergo self-renewing divisions.
Results: We developed a continuous-time Markov chain approach, based on the observation that changes in methylation state over tissue differentiation can be modeled similarly to DNA nucleotide changes over evolutionary time.
Moreover, the physical stimulations (e.g. electrical, mechanical, and photochemical stimulation) from the substrate can provide an additional dimension of control over the differentiation process of stem cells.
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